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Title: Impact of POR*28 on the Pharmacokinetics of Tacrolimus and Cyclosporine a in Renal Transplant Patients
Authors: Elens, Laure
Hesselink, Dennis A
Bouamar, Rachida
Budde, Klemens
de Fijter, Johannes W
De Meyer, Martine
Mourad, Michel
Kuypers, Dirk
Haufroid, Vincent
van Gelder, Teun
van Schaik, Ron H N
Issue Date: 20-Sep-2013
Publisher: Raven Press
Host Document: Therapeutic Drug Monitoring vol:35 issue:5 pages:709-709
Conference: 13th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology location:Salt Lake City date:sept 22-26, 2013
Article number: 24061445
Abstract: The P450 oxidoreductase (POR)*28 variant allele has been associated with altered cytochrome P450 3A enzyme activities. Both CYP3A5 and CYP3A4 are involved in the metabolism of calcineurin inhibitors and recent data show that POR*28 may explain part of the variability observed in tacrolimus (Tac) pharmacokinetics. The aim of this study was to investigate the impact of the POR*28 allele on Tac and cyclosporine A (CsA) immunosuppressive therapies.
ISSN: 0163-4356
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Laboratory of Nephrology

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