Title: Capacity of wild-type and chemokine-armed parvovirus H-1PV for inhibiting neo-angiogenesis
Authors: Lavie, Muriel ×
Struyf, Sofie
Stroh-Dege, Alexandra
Rommelaere, Jean
Van Damme, Jozef
Dinsart, Christiane #
Issue Date: Dec-2013
Publisher: Academic Press
Series Title: Virology vol:447 issue:1-2 pages:221-32
Article number: 10.1016/j.virol.2013.09.019
Abstract: Anti-angiogenic therapy has been recognized as a powerful potential strategy for impeding the growth of various tumors. However no major therapeutic effects have been observed to date, mainly because of the emergence of several resistance mechanisms. Among novel strategies to target tumor vasculature, some oncolytic viruses open up new prospects. In this context, we addressed the question whether the rodent parvovirus H-1PV can target endothelial cells. We show that cultures of human normal (HUVEC) and immortalized (KS-IMM) endothelial cells sustain an abortive viral cycle upon infection with H-1PV and are sensitive to H-1PV cytotoxicity. H-1PV significantly inhibits infected KS-IMM tumor growth. This effect may be traced back by the virus ability to both kill proliferating endothelial cells and inhibit VEGF production Recombinant H-1PV vectors can also transduce tumor cells with chemokines endowed with anti-angiogenesis properties, and warrant further validation for the treatment of highly vascularized tumors.
ISSN: 0042-6822
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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