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Title: Spinal cord stimulation modulates cerebral neurobiology: A proton magnetic resonance spectroscopy study
Authors: Moens, Maarten ×
Marien, Peter
Brouns, Raf
Poelaert, Jan
De Smedt, Anneke
Buyl, Ronald
Droogmans, Steven
Van Schuerbeek, Peter
Sunaert, Stefan
Nuttin, Bart #
Issue Date: 2013
Publisher: Springer-Verlag
Series Title: Neuroradiology vol:55 issue:8 pages:1039-1047
Abstract: Introduction
Although spinal cord stimulation (SCS) is a widely used treatment for chronic neuropathic pain secondary to spinal surgery, little is known about the underlying physiological mechanisms.
Methods
The primary aim of this study is to investigate the neural substrate underlying short-term SCS by means of 1H MR spectroscopy with short echo time, in 20 patients with failed back surgery syndrome.
Results
Marked increase of γ-aminobutyric acid (GABA) and decrease in glucose in the ipsilateral thalamus were found between baseline situation without SCS and after 9′ of SCS, indicating the key role of the ipsilateral thalamus as a mediator of chronic neuropathic pain. In addition, this study also showed a progressive decrease in glucose in the ipsilateral thalamus over time, which is in line with the findings of previous studies reporting deactivation in the ipsilateral thalamic region.
Conclusions
The observation of GABA increase and glucose decrease over time in the ipsilateral thalamus may be the causal mechanism of the pain relief due to SCS or an epiphenomenon.
ISSN: 0028-3940
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Electrical Engineering (ESAT) TC, Technology Campus Ostend
Technologiecluster ESAT Elektrotechnische Engineering
Groep Technologie en Design TM K - miscellaneous
Research Group Experimental Neurosurgery and Neuroanatomy
Translational MRI (+)
× corresponding author
# (joint) last author

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