Smad-interacting protein 1 affects acute and tonic, but not chronic pain
Pradier, B × Jeub, M Markert, A Mauer, D Tolksdorf, K Van de Putte, T Seuntjens, Eve Gailus-Durner, V Fuchs, H Hrabě de Angelis, M Huylebroeck, Danny Beck, H Zimmer, A Rácz, I #
European Federation of Chapters of the International Association for the Study of Pain
European Journal of Pain vol:18 issue:2 pages:249-257
Smad-interacting protein 1 (also named Zeb2 and Zfhx1b) is a transcription factor that plays an important role in neuronal development and, when mutated, causes Mowat-Wilson syndrome (MWS). A corresponding mouse model carrying a heterozygous Zeb2 deletion was comprehensively analysed in the German Mouse Clinic. The most prominent phenotype was the reduced pain sensitivity. In this study, we investigated the role of Zeb2 in inflammatory and neuropathic pain.