Title: Physiology of the upper segment, body, and lower segment of the esophagus
Authors: Miller, Larry ×
Clavé, Pere
Farre, Ricard
Lecea, Begoña
Ruggieri, Michael R
Ouyang, Ann
Regan, Julie
McMahon, Barry P #
Issue Date: Oct-2013
Publisher: New York Academy of Sciences
Series Title: Annals of the New York Academy of Sciences vol:1300 issue:1 pages:261-77
Article number: 10.1111/nyas.12250
Abstract: The following discussion on the physiology of the esophagus includes commentaries on the function of the muscularis mucosa and submucosa as a mechanical antireflux barrier in the esophagus; the different mechanisms of neurological control in the esophageal striated and smooth muscle; new insights from animal models into the neurotransmitters mediating lower esophageal sphincter (LES) relaxation, peristalsis in the esophageal body (EB), and motility of esophageal smooth muscle; differentiation between in vitro properties of the lower esophageal circular muscle, clasp muscle, and sling fibers; alterations in the relationship between pharyngeal contraction and relaxation of the upper esophageal sphincter (UES) in patients with dysphagia; the mechanical relationships between anterior hyoid movement, the extent of upper esophageal opening, and aspiration; the application of fluoroscopy and manometry with biomechanics to define the stages of UES opening; and nonpharmacological approaches to alter the gastroesophageal junction (GEJ).
ISSN: 0077-8923
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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