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Title: Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism
Authors: Vanuytsel, Tim
van Wanrooy, Sander
Vanheel, Hanne
Vanormelingen, Christophe
Verschueren, Sofie
Houben, Els
Salim Rasoel, Shadea
Tóth, Joran
Holvoet, Lieselot
Farre, Ricard
Van Oudenhove, Lukas
Boeckxstaens, Guy
Verbeke, Kristin
Tack, Jan # ×
Issue Date: Aug-2014
Publisher: BMJ Publishing Group
Series Title: Gut vol:63 issue:8 pages:1293-9
Article number: 10.1136/gutjnl-2013-305690
Abstract: Intestinal permeability and psychological stress have been implicated in the pathophysiology of IBD and IBS. Studies in animals suggest that stress increases permeability via corticotropin-releasing hormone (CRH)-mediated mast cell activation. Our aim was to investigate the effect of stress on intestinal permeability in humans and its underlying mechanisms.
ISSN: 0017-5749
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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