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Title: Text-derived concept profiles support assessment of DNA microarray data for acute myeloid leukemia and for androgen receptor stimulation
Authors: Jelier, Rob
Jenster, Guido
Dorssers, Lambert C J
Wouters, Bas J
Hendriksen, Peter J M
Mons, Barend
Delwel, Ruud
Kors, Jan A # ×
Issue Date: 2007
Publisher: BioMed Central
Series Title: BMC Bioinformatics vol:8
Article number: 14
Abstract: High-throughput experiments, such as with DNA microarrays, typically result in hundreds of genes potentially relevant to the process under study, rendering the interpretation of these experiments problematic. Here, we propose and evaluate an approach to find functional associations between large numbers of genes and other biomedical concepts from free-text literature. For each gene, a profile of related concepts is constructed that summarizes the context in which the gene is mentioned in literature. We assign a weight to each concept in the profile based on a likelihood ratio measure. Gene concept profiles can then be clustered to find related genes and other concepts.
URI: 
ISSN: 1471-2105
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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