Title: Central nervous system involvement in anaplastic large cell lymphoma in childhood: results from a multicentre European and Japanese study
Authors: Williams, Denise ×
Mori, Tetsuya
Reiter, Alfred
Woessman, Wilhelm
Rosolen, Angelo
Wrobel, Grazyna
Zsiros, Jozsef
Uyttebroeck, Anne
Marky, Ildiko
Le Deley, Marie-Cécile
Brugières, Laurence
European Intergroup for Childhood Non-Hodgkin Lymphoma, the Japanese Pediatric Leukemia/Lymphoma Study Group #
Issue Date: Oct-2013
Publisher: Wiley-Liss
Series Title: Pediatric Blood & Cancer vol:60 issue:10 pages:E118-21
Article number: 10.1002/pbc.24591
Abstract: In an international study of systemic childhood ALCL, 12/463 patients had CNS involvement, three of which had isolated CNS disease. Comparative analysis of CNS positive and negative patients showed no difference in ALK positivity, immunophenotype, presence of B symptoms or other sites of disease. The lymphohistiocytic variant was over represented in the CNS positive group (36% vs. 5%). With multi-agent chemotherapy, including high dose methotrexate, Ara-C and intrathecal treatment, the event free and overall survival of the CNS positive group at 5 years were 50% (95%CI, 25-75%) and 74% (45-91%), respectively with a median follow up of 4.1 years.
ISSN: 1545-5009
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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