Title: Prolonged mechanical ventilation alters the expression pattern of angio-neogenetic factors in a pre-clinical rat model
Authors: Bruells, Christian S ×
Maes, Karen
Rossaint, Rolf
Thomas, Debby
Cielen, Nele
Bleilevens, Christian
Bergs, Ingmar
Loetscher, Ursina
Dreier, Agnes
Gayan-Ramirez, Ghislaine
Behnke, Brad J
Weis, Joachim #
Issue Date: 2013
Publisher: Public Library of Sciene
Series Title: PLoS One vol:8 issue:8 pages:e70524
Article number: 10.1371/journal.pone.0070524
Abstract: Mechanical ventilation (MV) is a life saving intervention for patients with respiratory failure. Even after 6 hours of MV, diaphragm atrophy and dysfunction (collectively referred to as ventilator-induced diaphragmatic dysfunction, VIDD) occurs in concert with a blunted blood flow and oxygen delivery. The regulation of hypoxia sensitive factors (i.e. hypoxia inducible factor 1α, 2α (HIF-1α,-2α), vascular endothelial growth factor (VEGF)) and angio-neogenetic factors (angiopoietin 1-3, Ang) might contribute to reactive and compensatory alterations in diaphragm muscle.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pneumology
× corresponding author
# (joint) last author

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