Title: Comparative study on xanthan gum and hydroxypropylmethyl cellulose as matrices for controlled-release drug delivery .1. Compaction and in vitro drug release behaviour
Authors: Talukdar, MM ×
Michoel, Armand
Rombaut, P
Kinget, Renaat #
Issue Date: Mar-1996
Publisher: Elsevier science bv
Series Title: International journal of pharmaceutics vol:129 issue:1-2 pages:233-241
Abstract: A comparative investigation has been undertaken to assess the performance of xanthan gum (XG) and hydroxypropylmethyl cellulose (HPMC) as hydrophilic matrix-forming agents in respect of compaction characteristics and in vitro drug release behaviour. The overall compaction characteristics are found to be quite similar to each other and typical of polymer behaviour. But the flow characteristics are different, i.e., XG is more readily flowable than HPMC. The observed difference in drug release profiles between these two potential excipients are explored and explained by the difference in their hydrophilicity and subsequent hydration properties.
ISSN: 0378-5173
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
× corresponding author
# (joint) last author

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