Title: Alteration of the microRNA network during the progression of Alzheimer's disease
Authors: Lau Poui Cheung, Pierre
Bossers, Koen
Janky, Rekin's
Salta, Evgenia
Sala Frigerio, Carlo
Barbash, Shahar
Rothman, Roy
Sierksma, Annerieke
Thathiah, Amantha
Greenberg, David
Papadopoulou, Smaragda
Achsel, Tilmann
Ayoubi, Torik
Soreq, Hermona
Verhaagen, Joost
Swaab, Dick F
Aerts, Stein
De Strooper, Bart # ×
Issue Date: Oct-2013
Publisher: Wiley-Blackwell Publishing Ltd.
Series Title: EMBO Molecular Medicine vol:5 issue:10 pages:1613-34
Article number: 10.1002/emmm.201201974
Abstract: An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the hippocampus of a cohort of 41 late-onset AD (LOAD) patients and 23 controls, showing deregulation of 35 miRNAs. Profiling of miRNAs in the prefrontal cortex of a second independent cohort of 49 patients grouped by Braak stages revealed 41 deregulated miRNAs. We focused on miR-132-3p which is strongly altered in both brain areas. Downregulation of this miRNA occurs already at Braak stages III and IV, before loss of neuron-specific miRNAs. Next-generation sequencing confirmed a strong decrease of miR-132-3p and of three family-related miRNAs encoded by the same miRNA cluster on chromosome 17. Deregulation of miR-132-3p in AD brain appears to occur mainly in neurons displaying Tau hyper-phosphorylation. We provide evidence that miR-132-3p may contribute to disease progression through aberrant regulation of mRNA targets in the Tau network. The transcription factor (TF) FOXO1a appears to be a key target of miR-132-3p in this pathway.
ISSN: 1757-4676
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory for the Research of Neurodegenerative Diseases
× corresponding author
# (joint) last author

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