Title: Synthesis of an uncharged camp-analog
Authors: Ceulemans, G ×
Vandendriessche, F
Rozenski, Jef
Herdewijn, Piet #
Issue Date: 1995
Publisher: Marcel dekker inc
Series Title: Nucleosides & nucleotides vol:14 issue:1-2 pages:117-127
Abstract: 3'-O,5'-N-(N-phenylsulfonyliminocarbonyl)-5'-amino-5'-deoxy adenosine, an uncharged cAMP-analogue was synthesized. This was accomplished by treatment of 5'amino-5'-deoxy-2',3'-O-isopropylidene adenosine with dimethyl N-phenylsulfonyldithiocarbamate. After removal of the isopropylidene protecting group and treatment of the intermediate with benzoyl chloride, cyclisation was carried out in DMF containing 10 equivalents of potassium tert-butoxide. Final deprotection of the adenine moiety was carried out with hydrazine hydrate.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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