Title: Pharmaceutical performance of solid dispersions containing poly(ethylene glycol) 6000 and diazepam or temazepam
Authors: Verheyen, S ×
Blaton, Norbert
Kinget, Renaat
Van den Mooter, Guy #
Issue Date: 2004
Publisher: Kluwer academic publ
Series Title: Journal of thermal analysis and calorimetry vol:76 issue:2 pages:405-416
Abstract: Differential scanning calorimetry (DSC) data showed that the crystallinity of poly(ethylene glycol) 6000 in solid dispersions containing and diazepam or temazepam only slightly increased upon aging and that the twice folded modification of the polymer unfolded into the once folded modification during aging, while the once folded modification did not unfold. This unfolding was found to be time and temperature dependent. X-ray powder diffraction data revealed that the drug crystallinity in the solid dispersions slightly increased upon aging. The dissolution profiles of aged and non-aged solid dispersions were comparable. It was concluded that polymer unfolding did not have an impact on the pharmaceutical performance of the investigated dispersions.
ISSN: 1388-6150
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
× corresponding author
# (joint) last author

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