Title: 1,2,4-triazole derivatives inhibiting the human immunodeficiency virus type 1 (HIV-1) in vitro
Authors: Lagoja, Irene ×
Pannecouque, Christophe
Musumeci, Laura
Froeyen, Mathy
Van Aerschot, Arthur
Balzarini, Jan
Herdewijn, Piet
De Clercq, Erik #
Issue Date: 2002
Publisher: Wiley-v c h verlag gmbh
Series Title: Helvetica Chimica Acta vol:85 issue:7 pages:1883-1892
Abstract: A novel series of selective 1,2,4-triazole nonnucleoside reverse transcriptase inhibitors (NNRTIs) is described. In MT-4 cells compound, U inhibited human immunodeficiency virus type I (HIV-1) induced cytopathology at an IC50 of 9.98 muM with a selectivity index of 18.6. The hypothetical docking model of RUM derived from X-ray crystallographic structure of capravirine complex with HIV-1 RT links the activity profile to the H-bonding network.
ISSN: 0018-019X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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