Title: Detection of 2-amino-5-chloropyridine in urine as a parameter of zopiclone (Imovane(R)) intake using HPLC with diode array detection
Authors: Mannaert, E ×
Tytgat, Jan
Daenens, Paul #
Issue Date: May-1997
Publisher: Preston publications inc
Series Title: Journal of analytical toxicology vol:21 issue:3 pages:208-212
Abstract: A qualitative screening technique was developed for the detection of 2-amino-5-chloropyridine, a newly identified decomposition product of zopiclone and metabolites after alkaline hydrolysis of urine samples. The method was elaborated using a standard operation procedure (Merck Tox Screening System), combining a solid-phase extraction with reversed-phase high-performance liquid chromatography and diode array detection. The limit of detection, expressed as zopiclone concentrations in spiked urine, was found to be 0.5 microg/mL. Field urine samples from a volunteer were positive for 2-amino-5-chloropyridine until 16 h after ingestion of one therapeutic dose of Imovane (7.5 mg zopiclone).
ISSN: 0146-4760
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Toxicology and Pharmacology
× corresponding author
# (joint) last author

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