Title: Inactivation of urokinase-type plasminogen activator receptor (uPAR) gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice: a new model of experimental scleroderma?
Authors: Manetti, Mirko ×
Rosa, Irene
Milia, Anna Franca
Guiducci, Serena
Carmeliet, Peter
Ibba-Manneschi, Lidia
Matucci-Cerinic, Marco #
Issue Date: Sep-2014
Publisher: H.K. Lewis
Series Title: Annals of the Rheumatic Diseases vol:73 issue:9 pages:1700-9
Article number: 10.1136/annrheumdis-2013-203706
Abstract: Urokinase-type plasminogen activator receptor (uPAR) is a key component of the fibrinolytic system involved in extracellular matrix remodelling and angiogenesis. The cleavage/inactivation of uPAR is a crucial step in fibroblast-to-myofibroblast transition and has been implicated in systemic sclerosis (SSc) microvasculopathy. In the present study, we investigated whether uPAR gene inactivation in mice could result in tissue fibrosis and peripheral microvasculopathy resembling human SSc.
ISSN: 0003-4967
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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