ITEM METADATA RECORD
Title: Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
Authors: Welti, Jonathan ×
Loges, Sonja
Dimmeler, Stefanie
Carmeliet, Peter #
Issue Date: Aug-2013
Publisher: American Society for Clinical Investigation
Series Title: Journal of Clinical Investigation vol:123 issue:8 pages:3190-3200
Article number: 10.1172/JCI70212
Abstract: Four decades ago, angiogenesis was recognized as a therapeutic target for blocking cancer growth. Because of its importance, VEGF has been at the center stage of antiangiogenic therapy. Now, several years after FDA approval of an anti-VEGF antibody as the first antiangiogenic agent, many patients with cancer and ocular neovascularization have benefited from VEGF-targeted therapy; however, this anticancer strategy is challenged by insufficient efficacy, intrinsic refractoriness, and resistance. Here, we examine recent discoveries of new mechanisms underlying angiogenesis, discuss successes and challenges of current antiangiogenic therapy, and highlight emerging antiangiogenic paradigms.
URI: 
ISSN: 0021-9738
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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