Title: Role of Endothelial Cell Metabolism in Vessel Sprouting
Authors: De Bock, Katrien ×
Georgiadou, Maria
Carmeliet, Peter #
Issue Date: Nov-2013
Publisher: Cell Press
Series Title: Cell Metabolism vol:18 issue:5 pages:634-647
Article number: S1550-4131(13)00325-2
Abstract: Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis. Vascular sprouting relies on the coordinated activity of migrating tip cells at the forefront and proliferating stalk cells that elongate the sprout. Past studies have identified genetic signals that control vascular branching. Prominent are VEGF, activating tip cells, and Notch, which stimulates stalk cells. After the branch is formed and perfused, ECs become quiescent phalanx cells. Now, emerging evidence has accumulated indicating that ECs not only adapt their metabolism when switching from quiescence to sprouting but also that metabolism regulates vascular sprouting in parallel to the control by genetic signals.
ISSN: 1550-4131
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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