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Title: Control of vessel sprouting by genetic and metabolic determinants
Authors: Eelen, Guy ×
Cruys, Bert
Welti, Jonathan
De Bock, Katrien
Carmeliet, Peter #
Issue Date: Dec-2013
Publisher: Elsevier Science Pub. Co.
Series Title: Trends in Endocrinology and Metabolism vol:24 issue:12 pages:589-596
Article number: S1043-2760(13)00151-3
Abstract: Vessel sprouting by endothelial cells (ECs) during angiogenesis relies on a navigating tip cell and on proliferating stalk cells that elongate the shaft. To date, only genetic signals have been shown to regulate vessel sprouting. However, emerging evidence indicates that the angiogenic switch also requires a metabolic switch. Indeed, angiogenic signals not only induce a change in EC metabolism but this metabolic adaptation also co-determines vessel sprouting. The glycolytic activator PFKFB3 regulates stalk cell proliferation and renders ECs more competitive to reach the tip. We discuss the emerging link between angiogenesis and EC metabolism during the various stages of vessel sprouting, focusing only on genetic signals for which an effect on EC metabolism has been documented.
URI: 
ISSN: 1043-2760
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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