Title: Synthesis and labeling characteristics of tc-99m-mercaptoacetyltripeptides
Authors: Bormans, Guy ×
Cleynhens, Bernard
Adriaens, Paul
Deroo, M
Verbruggen, Alfons #
Issue Date: Nov-1993
Publisher: John wiley & sons ltd
Series Title: Journal of labelled compounds & radiopharmaceuticals vol:33 issue:11 pages:1065-1078
Abstract: A number of derivatives of mercaptoacetyltriglycine in which one or more of the three glycyl moieties are replaced by other amino acids such as D- or L-alanine, D-serine, D-2-aminobutyric acid, D-valine or D-phenylglycine have been synthesized and labelled with technetium-99m. Labelling with technetium yielded in each case a mixture of mainly two radioactive species, which probably are diastereomeric oxotechnetium (V) complexes originating from the presence of a chiral carbon atom in the ligands. The diastereomers were separated by reversed phase HPLC, Except for the serine derivative, all radiolabelled derivatives have a longer retention time than the parent compound Tc-99m-MAG3. The relative amount of the two diastereomers formed upon labelling is dependent on the nature of the ligand but can be influenced to a limited extent by the pH of the exchange labelling mixture.
ISSN: 0362-4803
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmacy
× corresponding author
# (joint) last author

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