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Title: Synthesis and anti-herpes activity of 5-trifluorovinyl-2'-deoxyuridine
Authors: Herdewijn, Piet ×
Kerremans, Lucien
Snoeck, Robert
Van Aerschot, Arthur
Esmans, E
De Clercq, Erik #
Issue Date: Sep-1992
Publisher: Pergamon-elsevier science ltd
Series Title: Bioorganic & medicinal chemistry letters vol:2 issue:9 pages:1057-1062
Abstract: 5-Trifluorovinyl-2'-deoxyuridine was synthesized from protected 5-iodo-2'-deoxyuridine and tetrakis(perfluorovinyl)tin. The compound demonstrates significant activity against HSV-1 but low activity against HSV-2.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Laboratory of Virology and Chemotherapy (Rega Institute)
Cell Metabolism
× corresponding author
# (joint) last author

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