Title: The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation
Authors: Lucá, Rossella ×
Averna, Michele
Zalfa, Francesca
Vecchi, Manuela
Bianchi, Fabrizio
Fata, Giorgio La
Del Nonno, Franca
Nardacci, Roberta
Bianchi, Marco
Nuciforo, Paolo
Munck, Sebastian
Parrella, Paola
Moura, Rute
Signori, Emanuela
Alston, Robert
Kuchnio, Anna
Farace, Maria Giulia
Fazio, Vito Michele
Piacentini, Mauro
De Strooper, Bart
Achsel, Tilmann
Neri, Giovanni
Neven, Patrick
Evans, D Gareth
Carmeliet, Peter
Mazzone, Max
Bagni, Claudia #
Issue Date: Oct-2013
Publisher: Wiley-Blackwell Publishing Ltd.
Series Title: EMBO Molecular Medicine vol:5 issue:10 pages:1523-1536
Article number: 10.1002/emmm.201302847
Abstract: The role of the fragile X mental retardation protein (FMRP) is well established in brain, where its absence leads to the fragile X syndrome (FXS). FMRP is almost ubiquitously expressed, suggesting that, in addition to its effects in brain, it may have fundamental roles in other organs. There is evidence that FMRP expression can be linked to cancer. FMR1 mRNA, encoding FMRP, is overexpressed in hepatocellular carcinoma cells. A decreased risk of cancer has been reported in patients with FXS while a patient-case with FXS showed an unusual decrease of tumour brain invasiveness. However, a role for FMRP in regulating cancer biology, if any, remains unknown. We show here that FMRP and FMR1 mRNA levels correlate with prognostic indicators of aggressive breast cancer, lung metastases probability and triple negative breast cancer (TNBC). We establish that FMRP overexpression in murine breast primary tumours enhances lung metastasis while its reduction has the opposite effect regulating cell spreading and invasion. FMRP binds mRNAs involved in epithelial mesenchymal transition (EMT) and invasion including E-cadherin and Vimentin mRNAs, hallmarks of EMT and cancer progression.
ISSN: 1757-4676
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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