Title: Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder
Authors: Sonuga-Barke, Edmund J. S ×
Brookes, Keeley-Joanne
Buitelaar, Jan
Anney, Richard
Bitsakou, Paraskevi
Baeyens, Dieter
Buschgens, Cathelijne
Chen, Wai
Christiansen, Hanna
Eisenberg, Jacques
Kuntsi, Jonna
Manor, Iris
Melia, Amanda
Mulligan, Aisling
Rommelse, Nanda
Mueller, Ueli C
Uebel, Henrik
Banaschewski, Tobias
Ebstein, Richard
Franke, Barbara
Gill, Michael
Miranda, Ana
Oades, Robert D
Roeyers, Herbert
Rothenberger, Aribert
Sergeant, Joseph
Steinhausen, Hans Christoph
Thompson, Margaret
Taylor, Eric
Asherson, Philip
Faraone, Stephen V #
Issue Date: 2008
Publisher: Wiley-Liss
Series Title: American Journal of Medical Genetics B, Neuropsychiatric Genetics vol:147B issue:3 pages:316-319
Abstract: A major goal of genetic studies of attention deficit hyperactivity disorder (ADHD) is to identify individual characteristics that might help segregate the disorder's inherent heterogeneity. [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] recently reported a potentially important association between two dopamine-related risk polymorphisms (DRD4 variable number tandem repeat (VNTR) in exon 3 and DAT1 VNTR in the 3' UTR) and lowered IQ in ADHD. The objective of the current study was to replicate the [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] findings in a clinical sample and to extend the analysis to a large range of alternative SNP markers of putative ADHD risk alleles identified in a recent study [Brookes et al. (2006); Mol Genet 11:934-953]. Participants were 1081 children and adolescents with a research-confirmed combined type ADHD diagnosis and 1300 unaffected siblings who took part in the International Multi-centre ADHD Genetics (IMAGE) project. They were recruited from multiple settings from across Europe: Belgium, Britain, Germany, Ireland, Israel, Netherlands, Spain and Switzerland. The results were that ADHD was associated with reduced IQ. However, there was no association between the two dopamine-related risk polymorphisms and IQ in either the probands or their siblings. Furthermore, other selected genetic markers previously demonstrated to be associated with ADHD in this sample were not associated with IQ. This large scale study with a clinically ascertained and regorously diagnosed sample failed to replicate the association between genetic polymorphisms in the dopamine system and IQ in ADHD. We also observed no association of other SNPs with IQ in ADHD. (C) 2007 Wiley-Liss, Inc.
ISSN: 1552-4841
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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