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Title: Effect of stabilizing versus destabilizing interactions on plasminogen activator inhibitor-1
Authors: Vleugels, Nele
Leys, J
Knockaert, I
Declerck, Paul # ×
Issue Date: Nov-2000
Publisher: F k schattauer verlag gmbh
Series Title: Thrombosis and haemostasis vol:84 issue:5 pages:871-875
Abstract: Plasminogen activator inhibitor-1 (PAI-1) is a unique member of the serpin family, as it spontaneously converts into a latent conformation. However, the exact mechanism of this conversion is not known. Previous studies reported that neutralizing monoclonal antibodies as well as reversal or removal of charges on the s3C-s4C turn results in a destabilization of PAI-1 leading to an accelerated conversion to its latent form.
ISSN: 0340-6245
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Pharmaceutical Biology (-)
× corresponding author
# (joint) last author

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