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Title: On hepatitis C virus evolution: the interaction between virus and host towards treatment outcome
Authors: Bittar, Cíntia ×
Jardim, Ana Carolina Gomes
Yamasaki, Lilian Hiromi Tomonari
Carareto, Claudia Márcia Aparecida
Pinho, João Renato Rebello
Lemey, Philippe
de Carvalho-Mello, Isabel Maria Vicente Guedes
Rahal, Paula #
Issue Date: 2013
Publisher: Public Library of Sciene
Series Title: PLoS One vol:8 issue:4 pages:e62393
Article number: 10.1371/journal.pone.0062393
Abstract: Hepatitis C is a disease spread throughout the world. Hepatitis C virus (HCV), the etiological agent of this disease, is a single-stranded positive RNA virus. Its genome encodes a single precursor protein that yields ten proteins after processing. NS5A, one of the non-structural viral proteins, is most associated with interferon-based therapy response, the approved treatment for hepatitis C in Brazil. HCV has a high mutation rate and therefore high variability, which may be important for evading the immune system and response to therapy. The aim of this study was to analyze the evolution of NS5A quasispecies before, during, and after treatment in patients infected with HCV genotype 3a who presented different therapy responses.
URI: 
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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