On hepatitis C virus evolution: the interaction between virus and host towards treatment outcome
Bittar, Cíntia × Jardim, Ana Carolina Gomes Yamasaki, Lilian Hiromi Tomonari Carareto, Claudia Márcia Aparecida Pinho, João Renato Rebello Lemey, Philippe de Carvalho-Mello, Isabel Maria Vicente Guedes Rahal, Paula #
Public Library of Sciene
PLoS One vol:8 issue:4 pages:e62393
Hepatitis C is a disease spread throughout the world. Hepatitis C virus (HCV), the etiological agent of this disease, is a single-stranded positive RNA virus. Its genome encodes a single precursor protein that yields ten proteins after processing. NS5A, one of the non-structural viral proteins, is most associated with interferon-based therapy response, the approved treatment for hepatitis C in Brazil. HCV has a high mutation rate and therefore high variability, which may be important for evading the immune system and response to therapy. The aim of this study was to analyze the evolution of NS5A quasispecies before, during, and after treatment in patients infected with HCV genotype 3a who presented different therapy responses.