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Title: Distinguishable epidemics of multidrug-resistant Salmonella Typhimurium DT104 in different hosts
Authors: Mather, A E ×
Reid, S W J
Maskell, D J
Parkhill, J
Fookes, M C
Harris, S R
Brown, D J
Coia, J E
Mulvey, M R
Gilmour, M W
Petrovska, L
de Pinna, E
Kuroda, M
Akiba, M
Izumiya, H
Connor, T R
Suchard, M A
Lemey, Philippe
Mellor, D J
Haydon, D T
Thomson, N R #
Issue Date: Sep-2013
Publisher: American Association for the Advancement of Science
Series Title: Science vol:341 issue:6153 pages:1514-1517
Article number: 10.1126/science.1240578
Abstract: The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and its resistance genes were largely maintained within animal and human populations separately and that there was limited transmission, in either direction. We also show considerable variation in the resistance profiles, in contrast to the largely stable bacterial core genome, which emphasizes the critical importance of integrated genotypic data sets in understanding the ecology of bacterial zoonoses and antimicrobial resistance.
URI: 
ISSN: 0036-8075
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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