Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years
Haupt, Riccardo × Minkov, Milen Astigarraga, Itziar Schaefer, Eva Nanduri, Vasanta Jubran, Rima Egeler, Maarten Janka, Gritta Micic, Dragan Rodriguez-Galindo, Carlos Van Gool, Stefaan Visser, Johannes Weitzman, Sheila Donadieu, Jean #
Pediatric Blood & Cancer vol:60 issue:2 pages:175-184
These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in peer reviewed publications. Existing guidelines were reviewed and changed where new evidence was available in the literature up to 2012. Data and publications have been ranked according to evidence based medicine and when there was a lack of published data, consensus between experts was sought. Guidelines for diagnosis, initial clinical work-up, and treatment and long-term follow-up of LCH patients are presented.