Title: Methylated hexitol nucleic acids, towards congeners with improved antisense potential
Authors: Van Aerschot, Arthur ×
Marchand, A
Schepers, Guy
Van den Eynde, W
Rozenski, Jef
Busson, Roger
Herdewijn, Piet #
Issue Date: 2003
Publisher: Marcel dekker inc
Series Title: Nucleosides nucleotides & nucleic acids vol:22 issue:5-8 pages:1227-1229
Abstract: In an effort to further improve the hybridisation potential of anhydro-hexitol nucleoside analogues, the 1'-methoxyl and 3'-methoxyl substituents were introduced and evaluated for their antisense potential. In view of the selectivity of pairing with RNA, especially the introduction of a 3'-O-alkyl moiety deserves further study.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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