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Title: Progressive Age-Related Cognitive Decline in Tau Mice
Authors: Van der Jeugd, Anneke ×
Vermaercke, Ben
Derisbourg, Maxime
Lo, Adrian
Hamdane, Malika
Blum, David
Buée, Luc
D'Hooge, Rudi #
Issue Date: Jul-2013
Publisher: IOS Press
Series Title: Journal of Alzheimer's Disease vol:37 issue:4 pages:777-788
Abstract: Age-related cognitive decline and neurodegenerative diseases are a growing challenge for society. Accumulation of tau pathology has been proposed to partially contribute to these impairments. This study provides a behavioral characterization during aging of transgenic mice bearing tau mutations. THY-Tau22 mice were evaluated at ages wherein tau neuropathology in this transgenic mouse model is low (3-4 months), moderate (6-7 months), or extensive (>9 months). Spatial memory was found to be impaired only after 9 months of age in THY-Tau22 mice, whereas non-spatial memory was affected as early as 6 months, appearing to offer an opportunity for assessing potential therapeutic agents in attenuating or preventing tauopathies through modulation of tau kinetics.
URI: 
ISSN: 1387-2877
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Biological Psychology
× corresponding author
# (joint) last author

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