Title: A neural network for predicting the stability of RNA/DNA hybrid duplexes
Authors: Ma, LX ×
Cheng, CM
Liu, XH
Zhao, YF
Wang, AL
Herdewijn, Piet #
Issue Date: 2004
Publisher: Elsevier science bv
Series Title: Chemometrics and intelligent laboratory systems vol:70 issue:2 pages:123-128
Abstract: A back propagation (BP) neural network (NN) method has been developed to predict the stability of RNA/DNA duplex. Calculated T-m of hybrid formation with the present parameters fits the experimental values within reasonable errors (AD = 1.2887 K, SEP = 1.782, R-2 = 0.9673 for NN1; AD = 2.1388 K, SEP = 3.506, R-2 = 0.8889 for NN2). And it has the advantage that the determinations of thermodynamic parameters (TP) are not needed. (C) 2004 Elsevier B.V. All rights reserved.
ISSN: 0169-7439
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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