Title: Synthesis and antiviral activity of 2-deoxy-1,5-anhydro-D-mannitol nucleosides containing a pyrimidine base moiety
Authors: Perez Perez, MJ ×
De Clercq, Erik
Herdewijn, Piet #
Issue Date: Jul-1996
Publisher: Pergamon-elsevier science ltd
Series Title: Bioorganic & medicinal chemistry letters vol:6 issue:13 pages:1457-1460
Abstract: Nucleoside analogues containing a 2-deoxy-1,5-anhydro-D-mannitol and a pyrimidine base moiety were synthesized starting from D-glucose via a nucleophilic opening of an epoxide with the heterocyclic base and an inversion of configuration at the 3'-position. Study of the conformation of these molecules, that show some activity against herpesviruses (HSV, VZV, CMV) should increase our understanding of the structural requirements of hexitol nucleosides for antiviral activity. Copyright (C) 1996 Elsevier Science Ltd
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cell Metabolism
Laboratory of Virology and Chemotherapy (Rega Institute)
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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