Title: Investigation of the kinetics of degradation of hexopyranosylated cytosine nucleosides using liquid chromatography
Authors: Thoithi, GN ×
Van Schepdael, Ann
Busson, Roger
Janssen, Gerardus
Van Aerschot, Arthur
Herdewijn, Piet
Roets, Eugene
Hoogmartens, Jos #
Issue Date: 2000
Publisher: Marcel Dekker
Series Title: Nucleosides, Nucleotides & Nucleic Acids vol:19 issue:1-2 pages:189-203
Abstract: Liquid chromatography was used to follow the degradation of hexopyranosylated cytosine nucleosides in buffers of acid, neutral and alkaline pH and of constant ionic strength. The compounds were found to degrade by hydrolysis to cytosine and/or by deamination to the corresponding uracil nucleosides. Degradation in acid is influenced by the number of sugar hydroxyl groups, presence of sugar double bonds and the type of anomer. Stability of some of the compounds was compared with that of related thymine nucleosides. Temperature studies support a unimolecular mechanism of hydrolysis at pH 1.22.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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