Title: Incorporation of 5-hydroxytryptophan in oligopeptides
Authors: Lescrinier, T
Busson, Roger
Rozenski, Jef
Janssen, Gerardus
Van Aerschot, Arthur
Herdewijn, Piet # ×
Issue Date: May-1996
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:52 issue:20 pages:6965-6972
Abstract: In the discovery of new inhibitors of enzymes, peptide libraries are actually representing a major point of interest. For this purpose, protecting group strategies are developed for the incorporation of modified amino acids in oligopeptides. Here we describe the incorporation of 5-hydroxytryptophan in oligopeptides using 5-O-benzyl-N-alpha-Fmoc-N-in-Boc-5-hydroxytryptophan as reagent. To evaluate the usefulness of this amino acid in solid phase peptide synthesis, protected 5-hydroxytryptophan was incorporated in a pentagastrine analogue. After deprotection, cleavage from the solid support, HPLC purification was performed and the identity of the obtained products was established by mass spectrometry. Copyright (C) 1996 Elsevier Science Ltd
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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