Title: Expanding the concepts and tools of metabolic engineering to elucidate cancer metabolism
Authors: Keibler, Mark A
Fendt, Sarah-Maria
Stephanopoulos, Gregory # ×
Issue Date: 18-Oct-2012
Publisher: American Institute of Chemical Engineers
Series Title: Biotechnology Progress vol:28 issue:6 pages:1409-18
Article number: 10.1002/btpr.1629
Abstract: The metabolic engineer's toolbox, comprising stable isotope tracers, flux estimation and analysis, pathway identification, and pathway kinetics and regulation, among other techniques, has long been used to elucidate and quantify pathways primarily in the context of engineering microbes for producing small molecules of interest. Recently, these tools are increasingly finding use in cancer biology due to their unparalleled capacity for quantifying intracellular metabolism of mammalian cells. Here, we review basic concepts that are used to derive useful insights about the metabolism of tumor cells, along with a number of illustrative examples highlighting the fundamental contributions of these methods to elucidating cancer cell metabolism. This area presents unique opportunities for metabolic engineering to expand its portfolio of applications into the realm of cancer biology and help develop new cancer therapies based on a new class of metabolically derived targets.
ISSN: 8756-7938
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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