Title: Effect of simmondsin derivatives on food intake: Dose-response curves in rats
Authors: Flo, Gerda ×
Van Boven, Maurits
Vermaut, S
Decuypere, Eddy
Daenens, Paul
Cokelaere, Marnix #
Issue Date: May-1998
Publisher: Amer chemical soc
Series Title: Journal of Agricultural and Food Chemistry vol:46 issue:5 pages:1910-1913
Abstract: Simmondsin is a food intake-reducing molecule found in the seeds of the jojoba plant (Simmondsia chinensis). Three naturally occurring analogues of simmondsin, simmondsin 2'-trans-ferulate, 4-demethylsimmondsin, and 4,5-didemethylsimmondsin, were tested for anorexic properties, and dose response curves were constructed. Demethylsimmondsin and didemethylsimmondsin showed no anorexic properties, while simmondsin 2'-trans-ferulate showed dose-dependent food intake-reducing activity, but, on an equimolar basis, was less active than simmondsin. The food intake-reducing activity of two synthetic derivatives of simmondsin, hydroxymethoxyphenylacetonitrile and simmondsinamide, was also determined, and both were found to be inactive.
ISSN: 0021-8561
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine, Campus Kulak Kortrijk
Toxicology and Pharmacology
Division of Livestock-Nutrition-Quality (-)
Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
× corresponding author
# (joint) last author

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