Title: Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
Authors: Fendt, Sarah-Maria
Bell, Eric L
Keibler, Mark A
Olenchock, Benjamin A
Mayers, Jared R
Wasylenko, Thomas M
Vokes, Natalie I
Guarente, Leonard
Vander Heiden, Matthew G
Stephanopoulos, Gregory # ×
Issue Date: 2013
Series Title: Nature Communications vol:4 pages:2236
Article number: 10.1038/ncomms3236
Abstract: Reductively metabolized glutamine is a major cellular carbon source for fatty acid synthesis during hypoxia or when mitochondrial respiration is impaired. Yet, a mechanistic understanding of what determines reductive metabolism is missing. Here we identify several cellular conditions where the α-ketoglutarate/citrate ratio is changed due to an altered acetyl-CoA to citrate conversion, and demonstrate that reductive glutamine metabolism is initiated in response to perturbations that result in an increase in the α-ketoglutarate/citrate ratio. Thus, targeting reductive glutamine conversion for a therapeutic benefit might require distinct modulations of metabolite concentrations rather than targeting the upstream signalling, which only indirectly affects the process.
ISSN: 2041-1723
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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