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Title: Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death
Authors: Huber, Heinrich ×
Laussmann, Maike A
Prehn, Jochen H M
Rehm, Markus #
Issue Date: 2010
Publisher: BioMed Central Ltd.
Series Title: BMC Systems Biology vol:4 pages:9
Article number: 10.1186/1752-0509-4-9
Abstract: Apoptosis is an essential cell death process throughout the entire life span of all metazoans and its deregulation in humans has been implicated in many proliferative and degenerative diseases. Mitochondrial outer membrane permeabilisation (MOMP) and activation of effector caspases are key processes during apoptosis signalling. MOMP can be subject to spatial coordination in human cancer cells, resulting in intracellular waves of cytochrome-c release. To investigate the consequences of these spatial anisotropies in mitochondrial permeabilisation on subsequent effector caspase activation, we devised a mathematical reaction-diffusion model building on a set of partial differential equations.
URI: 
ISSN: 1752-0509
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Cardiovascular Sciences - miscellaneous
× corresponding author
# (joint) last author

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