Title: Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy
Authors: Hector, Suzanne
Rehm, Markus
Schmid, Jasmin
Kehoe, Joan
McCawley, Niamh
Dicker, Patrick
Murray, Frank
McNamara, Deborah
Kay, Elaine W
Concannon, Caoimhin G
Huber, Heinrich
Prehn, Jochen H M # ×
Issue Date: May-2012
Publisher: BMJ Publishing Group
Series Title: Gut vol:61 issue:5 pages:725-733
Article number: 10.1136/gutjnl-2011-300433
Abstract: Key to the clinical management of colorectal cancer is identifying tools which aid in assessing patient prognosis and determining more effective and personalised treatment strategies. We evaluated whether an experimental systems biology strategy which analyses the susceptibility of cancer cells to undergo caspase activation can be exploited to predict patient responses to 5-fluorouracil-based chemotherapy and to case-specifically identify potential alternative targeted treatments to reactivate apoptosis.
ISSN: 0017-5749
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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