Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy
Hector, Suzanne Rehm, Markus Schmid, Jasmin Kehoe, Joan McCawley, Niamh Dicker, Patrick Murray, Frank McNamara, Deborah Kay, Elaine W Concannon, Caoimhin G Huber, Heinrich Prehn, Jochen H M # ×
BMJ Publishing Group
Gut vol:61 issue:5 pages:725-733
Key to the clinical management of colorectal cancer is identifying tools which aid in assessing patient prognosis and determining more effective and personalised treatment strategies. We evaluated whether an experimental systems biology strategy which analyses the susceptibility of cancer cells to undergo caspase activation can be exploited to predict patient responses to 5-fluorouracil-based chemotherapy and to case-specifically identify potential alternative targeted treatments to reactivate apoptosis.