Journal of labelled compounds & radiopharmaceuticals vol:31 issue:8 pages:575-588
The synthesis of [I-125]iodobuprenorphine is described. This compound has been used as a tracer molecule in the development of a nev radioimmunoassay for buprenorphine. The parameters that effect the direct iodination of buprenorphine using sodium [I-127]iodide, in the presence of either chloramine-T or Iodo-Beads(R), were previously studied. The structure of iodobuenorphine was confirmed by mass spectrometry.