Title: Task switching in traumatic brain injury relates to cortico-subcortical integrity
Authors: Leunissen, Inge ×
Coxon, James P
Caeyenberghs, Karen
Michiels, Karla
Sunaert, Stefan
Swinnen, Stephan #
Issue Date: May-2014
Publisher: Wiley-Liss
Series Title: Human Brain Mapping vol:35 issue:5 pages:2459-2469
Article number: 10.1002/hbm.22341
Abstract: Suppressing and flexibly adapting actions are a critical part of our daily behavioral repertoire. Traumatic brain injury (TBI) patients show clear impairments in this type of action control; however, the underlying mechanisms are poorly understood. Here, we tested whether white matter integrity of cortico-subcortical pathways could account for impairments in task switching, an important component of executive functioning. Twenty young adults with TBI and eighteen controls performed a switching task requiring attention to global versus local stimulus features. Diffusion weighted images were acquired and whole brain tract-based spatial statistics (TBSS) were used to explore where white matter damage was associated with switching impairment. A crossing fiber model and probabilistic tractography further identified the specific fiber populations. Relative to controls, patients with a history of TBI had a higher switch cost and were less accurate. The TBI group showed a widespread decline in fractional anisotropy (FA) throughout the TBSS skeleton. FA in the superior corona radiata showed a negative relationship with switch cost. More specifically, this involved cortico-subcortical loops with the (pre-)supplementary motor area and superior frontal gyrus. These findings provide evidence for damage to frontal-subcortical projections in TBI, which is associated with task switching impairments. Hum Brain Mapp, 2013. © 2013 Wiley Periodicals, Inc.
ISSN: 1065-9471
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Movement Control & Neuroplasticity Research Group
× corresponding author
# (joint) last author

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