Title: One-step synthesis of hypoxanthine from glycinamide and diformylurea
Authors: Lagoja, IM ×
Herdewijn, Piet #
Issue Date: 2004
Publisher: Verlag Helvetica Chimica Acta
Series Title: Chemistry & Biodiversity vol:1 issue:1 pages:106-111
Abstract: Because of their easy availability and their relative chemical stability, urea, formic acid, and glycine might have played a role in the assembly process of nucleobases. In this paper, a short reaction path is described to prepare hypoxanthine starting from the above mentioned precursors. The formation of hypoxanthine has been verified by high-resolution mass spectrometry with the N-15-labelled urea as starting material, and HPLC analysis. The yield of this condensation reaction has been determined spectrophotometrically.
ISSN: 1612-1872
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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