Title: Influence of threose nucleoside units on the catalytic activity of a hammerhead ribozyme
Authors: Kempeneers, Veerle ×
Froeyen, Mathy
Vastmans, K
Herdewijn, Piet #
Issue Date: 2004
Publisher: Verlag Helvetica Chimica Acta
Series Title: Chemistry & Biodiversity vol:1 issue:1 pages:112-123
Abstract: TNA (a-L-threose nucleic acids) is potentially a natural nucleic acid, that might have acted as an evolutionary alternative of RNA. We determined the catalytic activity of hammerhead ribozymes containing a threofuranosyl-modified nucleoside at position U-4 and U-7, and compared these results with those obtained from HNA (hexitol nucleic acids) insertion into the same ribozyme. Our experiments showed that, although the threofuranosyl-modified ribozymes still cleave the substrate strand, cleavage activity is highly decreased. It, therefore, seems that TNA can play a functional role in the RNA world, but only to a limited extent.
ISSN: 1612-1872
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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