ITEM METADATA RECORD
Title: Androgens and estrogens in skeletal sexual dimorphism
Authors: Laurent, MichaĆ«l ×
Antonio, Leen
Sinnesael, Mieke
Dubois, Vanessa
Gielen, Evelien
Claessens, Frank
Vanderschueren, Dirk #
Issue Date: 1-Mar-2014
Publisher: Science Press
Series Title: Asian Journal of Andrology vol:16 issue:2 pages:213-222
Article number: 10.4103/1008-682X.122356
Abstract: Bone is an endocrine tissue expressing androgen and estrogen receptors as well as steroid metabolizing enzymes. The bioactivity of circulating sex steroids is modulated by sex hormone-binding globulin and local conversion in bone tissue, for example, from testosterone (T) to estradiol (E2) by aromatase, or to dihydrotestosterone by 5α-reductase enzymes. Our understanding of the structural basis for gender differences in bone strength has advanced considerably over recent years due to increasing use of (high resolution) peripheral computed tomography. These microarchitectural insights form the basis to understand sex steroid influences on male peak bone mass and turnover in cortical vs trabecular bone. Recent studies using Cre/LoxP technology have further refi ned our mechanistic insights from global knockout mice into the direct contributions of sex steroids and their respective nuclear receptors in osteoblasts, osteoclasts, osteocytes, and other cells to male osteoporosis. At the same time, these studies have reinforced the notion that androgen and estrogen defi ciency have both direct and pleiotropic effects via interaction with, for example, insulin-like growth factor 1, inflammation, oxidative stress, central nervous system control of bone metabolism, adaptation to mechanical loading, etc., This review will summarize recent advances on these issues in the fi eld of sex steroid actions in male bone homeostasis.
URI: 
ISSN: 1008-682X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Endocrinology
Clinical and Experimental Endocrinology
Gerontology and Geriatrics
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
AJA_v16i2-1_M_Laurent.pdf Accepted 831KbAdobe PDFView/Open

 


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science