Title: Chromosomal translocations involving the IGH@ locus in B-cell precursor acute lymphoblastic leukemia: 29 new cases and a review of the literature
Authors: Chapiro, Elise ×
Radford-Weiss, Isabelle
Cung, Hong-Anh
Dastugue, Nicole
Nadal, Nathalie
Taviaux, Sylvie
Barin, Carole
Struski, Stephanie
Talmant, Pascaline
Vandenberghe, Peter
Mozziconacci, Marie-Joelle
Tigaud, Isabelle
Lefebvre, Christine
Penther, Dominique
Bastard, Christian
Lippert, Eric
Mugneret, Francine
Romana, Serge
Bernard, Olivier A
Harrison, Christine J
Russell, Lisa J
Nguyen-Khac, Florence
Groupe Francophone de Cytogénétique Hématologique #
Issue Date: May-2013
Series Title: Cancer Genetics vol:206 issue:5 pages:162-173
Article number: 10.1016/j.cancergen.2013.04.004
Abstract: Chromosomal translocations involving the immunoglobulin heavy chain locus (IGH@) are recurrent but rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL), and various partner genes have been described. Here, we report a new series of 29 cases of BCP-ALL with IGH@ translocations. The partner gene was identified by fluorescence in situ hybridization and/or molecular cloning in 20 patients. Members of the CEBP gene family (n = 11), BCL2 (n = 3), ID4 (n = 3), EPOR (n = 2), and TRA/D@ (n = 1) were identified and demonstrated by quantitative real-time reverse transcriptase-polymerase chain reaction to be markedly up-regulated. The present cases, added to those already reported, confirm the diversity of the partner genes, which, apart from BCL2, are specific to BCP-ALL. Collectively, patients with IGH@ translocations may represent a novel sub-group of BCP-ALL occurring in adolescents and young adults.
ISSN: 2210-7762
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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