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Title: Context-dependent codon partition models provide significant increases in model fit in atpB and rbcL protein-coding genes
Authors: Baele, Guy
Van de Peer, Yves ×
Vansteelandt, Stijn #
Issue Date: 2011
Publisher: BioMed Central
Series Title: BMC Evolutionary Biology vol:11 pages:145
Article number: 10.1186/1471-2148-11-145
Abstract: Accurate modelling of substitution processes in protein-coding sequences is often hampered by the computational burdens associated with full codon models. Lately, codon partition models have been proposed as a viable alternative, mimicking the substitution behaviour of codon models at a low computational cost. Such codon partition models however impose independent evolution of the different codon positions, which is overly restrictive from a biological point of view. Given that empirical research has provided indications of context-dependent substitution patterns at four-fold degenerate sites, we take those indications into account in this paper.
URI: 
ISSN: 1471-2148
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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