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Title: Using non-reversible context-dependent evolutionary models to study substitution patterns in primate non-coding sequences
Authors: Baele, Guy ×
Van de Peer, Yves
Vansteelandt, Stijn #
Issue Date: Jul-2010
Publisher: Springer Verlag
Series Title: Journal of Molecular Evolution vol:71 issue:1 pages:34-50
Article number: 10.1007/s00239-010-9362-y
Abstract: We discuss the importance of non-reversible evolutionary models when analyzing context-dependence. Given the inherent non-reversible nature of the well-known CpG-methylation-deamination process in mammalian evolution, non-reversible context-dependent evolutionary models may be well able to accurately model such a process. In particular, the lack of constraints on non-reversible substitution models might allow for more accurate estimation of context-dependent substitution parameters. To demonstrate this, we have developed different time-homogeneous context-dependent evolutionary models to analyze a large genomic dataset of primate ancestral repeats based on existing independent evolutionary models. We have calculated the difference in model fit for each of these models using Bayes Factors obtained via thermodynamic integration. We find that non-reversible context-dependent models can drastically increase model fit when compared to independent models and this on two primate non-coding datasets. Further, we show that further improvements are possible by clustering similar parameters across contexts.
URI: 
ISSN: 0022-2844
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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