ITEM METADATA RECORD
Title: Modelling the ancestral sequence distribution and model frequencies in context-dependent models for primate non-coding sequences
Authors: Baele, Guy ×
Van de Peer, Yves
Vansteelandt, Stijn #
Issue Date: 2010
Publisher: BioMed Central
Series Title: BMC Evolutionary Biology vol:10 issue:244 pages:1-21
Article number: 10.1186/1471-2148-10-244
Abstract: Recent approaches for context-dependent evolutionary modelling assume that the evolution of a given site depends upon its ancestor and that ancestor's immediate flanking sites. Because such dependency pattern cannot be imposed on the root sequence, we consider the use of different orders of Markov chains to model dependence at the ancestral root sequence. Root distributions which are coupled to the context-dependent model across the underlying phylogenetic tree are deemed more realistic than decoupled Markov chains models, as the evolutionary process is responsible for shaping the composition of the ancestral root sequence.
URI: 
ISSN: 1471-2148
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Baele_VandePeer_Vansteelandt - Modelling the ancestral sequence distribution and model frequencies in context-dependent models for primate non-coding sequences.pdf Published 2225KbAdobe PDFView/Open

 


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science