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Title: Interlaboratory study of the analysis of benzylpenicillin by liquid chromatography
Authors: Roets, Eugene ×
Loidl, J
Inama, P
Perez, A
Porqueras, E
Wachberger, E
Lebbe, C
Smelt, AJW
Van der Vlies, C
Miller, JH McB
Spieser, JM
Hoogmartens, Jos
Yongxin, Z #
Issue Date: Apr-1998
Publisher: Elsevier science bv
Series Title: Journal of chromatography. B, Biomedical sciences and applications vol:707 issue:1-2 pages:189-93
Abstract: A liquid chromatography method for analysis of benzylpenicillin was examined in a collaborative study involving seven laboratories. The method comprised an isocratic part, which is used in the assay. The isocratic part corresponds to the assay method for benzylpenicillin used by a manufacturer. When the isocratic part is combined with gradient elution, the method is suitable for purity control. Five samples of benzylpenicillin (sodium and potassium salts) were analysed. The main component and the impurities were determined. An analysis of variance proved the absence of consistent laboratory bias. The laboratory-sample interaction was not significant. Estimates for the repeatability and reproducibility of the method, expressed as standard deviations (S.D.) of the result of the determination of benzylpenicillin, were calculated to be 0.71 and 0.80, respectively. (C) 1998 Elsevier Science B.V.
ISSN: 0378-4347
1387-2273
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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