Title: The Intracellular Sensor NOD2 Induces MicroRNA-29 Expression in Human Dendritic Cells to Limit IL-23 Release
Authors: Brain, Oliver *
Owens, Benjamin M J *
Pichulik, Tica
Allan, Philip
Khatamzas, Elham
Steevels, Tessa
Mayer, Alice
Catuneanu, Ana Maria
Morton, Victoria
Jewell, Derek
Coccia, Margherita
Harrison, Oliver
Maloy, Kevin
Schönefeldt, Susann
Bornschein, Simon
Liston, Adrian
Simmons, Alison # ×
Issue Date: Sep-2013
Publisher: Cell Press
Series Title: Immunity vol:39 issue:3 pages:521-36
Article number: 10.1016/j.immuni.2013.08.035
Abstract: NOD2 is an intracellular sensor that contributes to immune defense and inflammation. Here we investigated whether NOD2 mediates its effects through control of microRNAs (miRNAs). miR-29 expression was upregulated in human dendritic cells (DCs) in response to NOD2 signals, and miR-29 regulated the expression of multiple immune mediators. In particular, miR-29 downregulated interleukin-23 (IL-23) by targeting IL-12p40 directly and IL-23p19 indirectly, likely via reduction of ATF2. DSS-induced colitis was worse in miR-29-deficient mice and was associated with elevated IL-23 and T helper 17 signature cytokines in the intestinal mucosa. Crohn's disease (CD) patient DCs expressing NOD2 polymorphisms failed to induce miR-29 upon pattern recognition receptor stimulation and showed enhanced release of IL-12p40 on exposure to adherent invasive E. coli. Therefore, we suggest that loss of miR-29-mediated immunoregulation in CD DCs might contribute to elevated IL-23 in this disease.
ISSN: 1074-7613
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Genetics of Autoimmunity
* (joint) first author
× corresponding author
# (joint) last author

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