Title: Development and validation of an improved liquid chromatographic method for the analysis of dirithromycin
Authors: Diana, Jose ×
Manyanga, Vicky
Hoogmartens, Jos
Adams, Erwin #
Issue Date: Dec-2006
Publisher: Elsevier science bv
Series Title: Talanta vol:70 issue:5 pages:1064-1072
Abstract: The official method for the determination of dirithromycin and related substances in the European Pharmacopoeia (Ph. Eur.) and in the United States Pharmacopeia (USP) is an isocratic liquid chromatographic (LC) method using an ODS column. With this method, the separation of the main component dirithromycin from its epimer is not complete. Moreover, this method suffers sometimes from drift of the baseline and from subsequent quantitation problems. The required resolution is not easy to obtain.
ISSN: 0039-9140
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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